Modelling the interaction between bacteriophages and their bacterial hosts

Gabor Beke; Matej Stano; Lubos Klucar

doi:10.1016/j.mbs.2016.06.009

Modelling the interaction between bacteriophages and their bacterial hosts

Math Biosci. 2016 Sep:279:27-32. doi: 10.1016/j.mbs.2016.06.009. Epub 2016 Jul 5.

Authors

Gabor Beke¹, Matej Stano², Lubos Klucar³

Affiliations

¹ Institute of Molecular Biology SAS, Laboratory of Bioinformatics, Dubravska cesta 21, 84551 Bratislava, Slovakia . Electronic address: gabor.beke@savba.sk.
² Institute of Molecular Biology SAS, Laboratory of Bioinformatics, Dubravska cesta 21, 84551 Bratislava, Slovakia . Electronic address: matej.stano@savba.sk.
³ Institute of Molecular Biology SAS, Laboratory of Bioinformatics, Dubravska cesta 21, 84551 Bratislava, Slovakia . Electronic address: lubos.klucar@savba.sk.

PMID: 27393678
DOI: 10.1016/j.mbs.2016.06.009

Abstract

A mathematical model simulating the interaction between bacteriophages and their bacterial hosts has been developed. It is based on other known models describing this type of interaction, enhanced with an ability to model the system influenced by other environmental factor such as pH and temperature. This could be used for numerous estimations of growth rate, when the pH and/or the temperature of the environment are not constant. The change of pH or the temperature greatly affects the specific growth rate which has an effect on the final results of the simulation. Since the model aims on practical application and easy accessibility, an interactive website has been developed where users can run simulations with their own parameters and easily calculate and visualise the result of simulation. The web simulation is accessible at the URL http://www.phisite.org/model.

Keywords: Bacteria; Bacteriophage; Model; Phage therapy.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bacteria*
Bacterial Physiological Phenomena*
Bacteriophages*
Models, Theoretical*