Early mobilization versus bed rest for deep vein thrombosis

Medwave. 2016 Jun 28:16 Suppl 2:e6478. doi: 10.5867/medwave.2016.6478.
[Article in English, Spanish]

Abstract

Aiming to prevent thromboembolic events, bed rest was historically considered in the management of patient with deep vein thrombosis. Nevertheless early ambulation could have beneficial effects. Searching in Epistemonikos database, which is maintained by screening 30 databases, we identified seven systematic reviews including 10 randomized trials answering this question. We combined the evidence using meta-analysis and generated a summary of findings table following the GRADE approach. We concluded early ambulation is probably effective in reducing deep vein thrombosis progression and improving limb pain, and might not increase the risk of thromboembolism.

Históricamente el reposo en cama fue incluido como parte del esquema de manejo de pacientes con trombosis venosa profunda con el objetivo de evitar eventos tromboembólicos. Sin embargo, la deambulación precoz podría asociarse a beneficios importantes. Utilizando la base de datos Epistemonikos, la cual es mantenida mediante búsquedas en 30 bases de datos, identificamos siete revisiones sistemáticas que en conjunto incluyen 10 estudios controlados aleatorizados pertinentes. Realizamos un metanálisis y tablas de resumen de los resultados utilizando el método GRADE. Concluimos que la deambulación temprana probablemente disminuye el dolor y el riesgo de progresión de la trombosis, y podría no aumentar el riesgo de tromboembolismo pulmonar.

Publication types

  • Comparative Study
  • Meta-Analysis
  • Review

MeSH terms

  • Bed Rest / methods*
  • Disease Progression
  • Early Ambulation / methods*
  • Humans
  • Randomized Controlled Trials as Topic
  • Thromboembolism / prevention & control
  • Venous Thrombosis / pathology
  • Venous Thrombosis / therapy*