Viral Noncoding RNAs in Cancer Biology

Adv Exp Med Biol. 2016:927:367-89. doi: 10.1007/978-981-10-1498-7_14.

Abstract

Over 12 % of all human cancers are caused by oncoviruses, primarily including Epstein-Barr virus (EBV), high-risk human papillomaviruses (HPVs), hepatitis B and C viruses (HBV and HCV, respectively), and Kaposi's sarcoma herpesvirus (KSHV). In addition to viral oncoproteins, a variety of noncoding RNAs (ncRNAs) produced by oncoviruses have been recognized as important cofactors that contribute to the oncogenic events. In this chapter, we will focus on the recent understanding of the long and short noncoding RNAs, as well as microRNAs of the viruses, and discuss their roles in the biology of multistep oncogenesis mediated by established human oncoviruses.

Keywords: Cancer; MicroRNAs; Noncoding RNA; Oncoviruses.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Gene Expression Regulation, Neoplastic
  • Hepacivirus / genetics
  • Hepacivirus / pathogenicity
  • Hepatitis B virus / genetics
  • Hepatitis B virus / pathogenicity
  • Herpesvirus 4, Human / genetics
  • Herpesvirus 4, Human / pathogenicity
  • Herpesvirus 8, Human / genetics
  • Herpesvirus 8, Human / pathogenicity
  • Humans
  • MicroRNAs / genetics*
  • Neoplasms / genetics*
  • Neoplasms / pathology
  • Neoplasms / virology
  • Papillomaviridae / genetics
  • Papillomaviridae / pathogenicity
  • RNA, Long Noncoding / genetics*
  • RNA, Small Untranslated / genetics*

Substances

  • MicroRNAs
  • RNA, Long Noncoding
  • RNA, Small Untranslated