Cardioprotection by Phytochemicals via Antiplatelet Effects and Metabolism Modulations

Cell Biochem Biophys. 2015 Nov;73(2):369-379. doi: 10.1007/s12013-015-0612-x.

Abstract

The multi-factorial aetiology is the characteristic element of cardiac disorders. Further scientific research had recognized for a long time that platelet function is related to the risk of developing atherosclerosis. Activated blood platelets play a central role in this chronic inflammatory condition as they contribute to plaque formation within blood vessels in the early stages of atherogenesis. The present review article summarizes the cardioprotective role played by Phytochemicals via antiplatelet effects. Also, various metabolic modifications have been included that have protective effect during cardiac pathology.

Keywords: Antiplatelet effects; Cardioprotection; Curcumin; Metabolism modulation; Phenolics; Phytochemical; Polyphenols; Resveratrol.

Publication types

  • Review

MeSH terms

  • Animals
  • Blood Platelets / drug effects*
  • Cardiotonic Agents / pharmacology*
  • Cardiotonic Agents / therapeutic use
  • Cardiovascular Diseases / prevention & control
  • Flavonoids / chemistry
  • Flavonoids / pharmacology
  • Flavonoids / therapeutic use
  • Humans
  • Lignans / chemistry
  • Lignans / pharmacology
  • Lignans / therapeutic use
  • Phytochemicals / pharmacology*
  • Phytochemicals / therapeutic use
  • Platelet Aggregation Inhibitors / pharmacology*
  • Platelet Aggregation Inhibitors / therapeutic use
  • Polyphenols / chemistry
  • Polyphenols / pharmacology
  • Polyphenols / therapeutic use
  • Stilbenes / chemistry
  • Stilbenes / pharmacology
  • Stilbenes / therapeutic use
  • Tannins / chemistry
  • Tannins / pharmacology
  • Tannins / therapeutic use

Substances

  • Cardiotonic Agents
  • Flavonoids
  • Lignans
  • Phytochemicals
  • Platelet Aggregation Inhibitors
  • Polyphenols
  • Stilbenes
  • Tannins