Fungal proteinaceous compounds with multiple biological activities

Appl Microbiol Biotechnol. 2016 Aug;100(15):6601-6617. doi: 10.1007/s00253-016-7671-9. Epub 2016 Jun 23.

Abstract

Fungi comprise organisms like molds, yeasts and mushrooms. They have been used as food or medicine for a long time. A large number of fungal proteins or peptides with diverse biological activities are considered as antibacterial, antifungal, antiviral and anticancer agents. They encompass proteases, ribosome inactivating proteins, defensins, hemolysins, lectins, laccases, ribonucleases, immunomodulatory proteins, and polysaccharopeptides. The target of the present review is to update the status of the various bioactivities of these fungal proteins and peptides and discuss their therapeutic potential.

Keywords: Antibacterial; Anticancer; Antifungal; Antiviral; Fungi; Proteins.

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Antifungal Agents / pharmacology
  • Antineoplastic Agents / pharmacology
  • Antiviral Agents / pharmacology
  • Cell Proliferation / drug effects
  • Defensins / pharmacology
  • Fungal Proteins / metabolism*
  • Fungal Proteins / pharmacology*
  • Fungi / metabolism*
  • Immunologic Factors / pharmacology
  • Ribosome Inactivating Proteins / pharmacology

Substances

  • Anti-Bacterial Agents
  • Antifungal Agents
  • Antineoplastic Agents
  • Antiviral Agents
  • Defensins
  • Fungal Proteins
  • Immunologic Factors
  • Ribosome Inactivating Proteins