Abstract
An efficient approach for the synthesis of Z-1,3-enynes based on the coupling reaction of Z-vinyl tellurides and alkynes containing a pseudoglycoside moiety is described. The products were obtained in good yields via a stereoselective way. Preliminary screening against three tumor cell lines indicated that the synthesized compounds are promising intermediates for the synthesis of an array of more potent target structures.
MeSH terms
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Alkynes / chemical synthesis*
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Alkynes / chemistry
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Alkynes / pharmacology*
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Cell Survival / drug effects
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Glycosides / chemical synthesis
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Glycosides / chemistry
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Glycosides / pharmacology
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Humans
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Neoplasms / drug therapy
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Stereoisomerism
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Tellurium / chemistry*
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Tellurium / pharmacology
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Vinyl Compounds / chemistry
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Vinyl Compounds / pharmacology
Substances
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Alkynes
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Antineoplastic Agents
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Glycosides
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Vinyl Compounds
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Tellurium