Metacycloprodigiosin induced cell death selectively in β-catenin-mutated tumor cells

J Antibiot (Tokyo). 2017 Jan;70(1):109-112. doi: 10.1038/ja.2016.75. Epub 2016 Jun 22.

Authors

Hiroaki Ikeda¹, Yuki Shikata¹, Ramida Watanapokasin², Etsu Tashiro¹, Masaya Imoto¹

Affiliations

¹ Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University, Yokohama, Japan.
² Department of Biochemistry, Faculty of Medicine, Srinakharinwirot University, Bangkok, Thailand.

PMID: 27328865
DOI: 10.1038/ja.2016.75

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Apoptosis / drug effects*
Cell Line, Tumor
Humans
Mutation*
Prodigiosin / analogs & derivatives*
Prodigiosin / pharmacology
Vacuolar Proton-Translocating ATPases / antagonists & inhibitors*
beta Catenin / genetics*

Substances

CTNNB1 protein, human
beta Catenin
metacycloprodigiosin
Vacuolar Proton-Translocating ATPases
Prodigiosin