Innate Immune Memory: Activation of Macrophage Killing Ability by Developmental Duties

David Schneider; Ann Thomas Tate

doi:10.1016/j.cub.2016.05.016

Innate Immune Memory: Activation of Macrophage Killing Ability by Developmental Duties

Curr Biol. 2016 Jun 20;26(12):R503-R505. doi: 10.1016/j.cub.2016.05.016.

Authors

David Schneider¹, Ann Thomas Tate²

Affiliations

¹ Department of Microbiology and Immunology, Stanford University, Stanford, CA, USA. Electronic address: dschneid@stanford.edu.
² Department of Biology and Biochemistry, University of Houston, Houston, TX, USA.

PMID: 27326712
DOI: 10.1016/j.cub.2016.05.016

Abstract

Innate immune systems in many taxa exhibit hallmarks of memory in response to previous microbial exposure. A new study demonstrates that innate immune memory in Drosophila embryonic macrophages can also be induced by the successful engulfment of apoptotic cells, highlighting the importance of early exposure events for developing responsive immune systems.

Publication types

Comment

MeSH terms

Animals
Drosophila
Immunity, Innate*
Immunologic Memory*
Macrophages / physiology*