Face graft? Extrapolation of facial allotransplantation to children

J Craniomaxillofac Surg. 2016 Aug;44(8):925-33. doi: 10.1016/j.jcms.2016.03.006. Epub 2016 Apr 21.

Abstract

The possibility to imagine a vascularized composite allotransplantation for disfigured children is felt more critical than for adults non on technical point of view but in terms of indications and justifications. The question is not about surgery. It is related to the pathologies themselves for which transplant could be suitable. Moreover the procurement of face transplant will be more difficult because of immunologic criteria but also age and phototype. Specificity of the newborn malformative face is usually not only a question of tissue defect. It is reasonably not an indication for VCA. It should be added that nothing is known about the future of transplantation in terms of duration but also morbidities due to immunosuppression. Indications are rather negative. To rise the question of VCA for children has a double benefit. The first is to point out that surgical innovation often arise from a non imaginable or non imagined clinical situation. The second is the question of VCA in newborn regarding the tolerance.

Keywords: Allotransplantation; Face reconstruction; Immunosuppression; Microsurgery; Reconstructive microsurgery.

MeSH terms

  • Adolescent
  • Adult
  • Burns / surgery*
  • Child
  • Face / abnormalities
  • Face / surgery*
  • Facial Injuries / surgery*
  • Facial Transplantation*
  • Female
  • Humans
  • Infant, Newborn
  • Male
  • Transplantation, Homologous