Pinched by RNA "fingers": Long noncoding RNAs hitting signal transduction pathways

Bodu Liu; Lijuan Sun; Erwei Song

doi:10.1080/23723556.2015.1046582

Pinched by RNA "fingers": Long noncoding RNAs hitting signal transduction pathways

Mol Cell Oncol. 2016 Mar 16;3(3):e1046582. doi: 10.1080/23723556.2015.1046582. eCollection 2016 May.

Authors

Bodu Liu¹, Lijuan Sun², Erwei Song¹

Affiliations

¹ Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China; Key Laboratory of Gene Engineering of Ministry of Education, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, China.
² Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.

Abstract

We have recently reported a long noncoding RNA that interacts with nuclear factor κB (NFκB) and represses NFκB activation by physically masking the phosphorylation site of inhibitor of NFκB (IκB). Our findings have revealed a new class of long noncoding RNAs (lncRNAs) that directly interact with proteins involved in signal transduction pathways and interfere with cell signaling. This implicates a potential strategy for the design of RNA-based targeted drugs.

Keywords: Cancer; NFκB; long noncoding RNA; signal pathway; targeted therapy.