Target Delivery of a Novel Antitumor Organoplatinum(IV)-Substituted Polyoxometalate Complex for Safer and More Effective Colorectal Cancer Therapy In Vivo

Tiedong Sun; Wei Cui; Mei Yan; Geng Qin; Wei Guo; Hongxi Gu; Shaoqin Liu; Qiong Wu

doi:10.1002/adma.201601778

Target Delivery of a Novel Antitumor Organoplatinum(IV)-Substituted Polyoxometalate Complex for Safer and More Effective Colorectal Cancer Therapy In Vivo

Adv Mater. 2016 Sep;28(34):7397-404. doi: 10.1002/adma.201601778. Epub 2016 Jun 16.

Authors

Tiedong Sun^{1

2}, Wei Cui², Mei Yan¹, Geng Qin², Wei Guo^{1

2}, Hongxi Gu^{1

2}, Shaoqin Liu³, Qiong Wu⁴

Affiliations

¹ Key Laboratory of Microsystems and Microstructures Manufacturing, Ministry of Education, Harbin Institute of Technology, Harbin, 150080, P. R. China.
² School of Life Science and Technology, Harbin Institute of Technology, Harbin, 150080, P. R. China.
³ Key Laboratory of Microsystems and Microstructures Manufacturing, Ministry of Education, Harbin Institute of Technology, Harbin, 150080, P. R. China. shaoqinliu@hit.edu.cn.
⁴ School of Life Science and Technology, Harbin Institute of Technology, Harbin, 150080, P. R. China. kigo@hit.edu.cn.

PMID: 27309631
DOI: 10.1002/adma.201601778

Abstract

An inactive organoplatinum(IV)-substituted polyoxometalate is developed as an efficient and nontoxic prodrug with significant potential for treating human colorectal cancers. Further encapsulation of Pt(IV) -PW11 with DSPE-PEG2000 nanoparticles (NPs) enables targeted delivery and controlled release of inactive prodrug. Such Pt(IV) -PW11 -DSPE-PEG2000 NPs are highly efficient in inhibiting cellular growth of HT29 cells and treating human colorectal cancer in mice, superior to classic cisplatin.

Keywords: antitumor activity; micelles; polyoxometalates; target delivery.

MeSH terms

Animals
Antineoplastic Agents
Cell Line, Tumor
Cisplatin
Colorectal Neoplasms*
Drug Delivery Systems
Humans
Mice
Nanoparticles
Prodrugs
Tungsten Compounds

Substances

Antineoplastic Agents
Prodrugs
Tungsten Compounds
polyoxometalate I
Cisplatin