Cascade C-H Functionalization/Amidation Reaction for Synthesis of Azepinone Derivatives

Peng Bai; Xing-Fen Huang; Guo-Dong Xu; Zhi-Zhen Huang

doi:10.1021/acs.orglett.6b01140

Cascade C-H Functionalization/Amidation Reaction for Synthesis of Azepinone Derivatives

Org Lett. 2016 Jul 1;18(13):3058-61. doi: 10.1021/acs.orglett.6b01140. Epub 2016 Jun 16.

Authors

Peng Bai¹, Xing-Fen Huang¹, Guo-Dong Xu¹, Zhi-Zhen Huang^{1

2}

Affiliations

¹ Department of Chemistry, Zhejiang University , Hangzhou 310028, P. R. China.
² State Key Laboratory of Elemento-organic Chemistry, Nankai University , Tianjin 300071, P. R. China.

PMID: 27308722
DOI: 10.1021/acs.orglett.6b01140

Abstract

A cascade C-H functionalization/amidation reaction of aminobiaryls with diazomalonates has been developed under rhodium catalysis, affording new azepinone derivatives in moderate to excellent yields.

Publication types

Research Support, Non-U.S. Gov't