TopBP1 makes the final call for repair on the verge of cell division

Vibe H Oestergaard; Michael Lisby

doi:10.1080/23723556.2015.1093066

TopBP1 makes the final call for repair on the verge of cell division

Mol Cell Oncol. 2015 Dec 10;3(2):e1093066. doi: 10.1080/23723556.2015.1093066. eCollection 2016 Mar.

Authors

Vibe H Oestergaard¹, Michael Lisby¹

Affiliation

¹ Department of Biology, University of Copenhagen , Copenhagen, Denmark.

Abstract

Mitosis is the process responsible for segregation of the duplicated genome into 2 new daughter cells. We recently identified an important function of the protein TopBP1 during mitosis by showing that TopBP1 suppresses transmission of DNA damage to daughter cells. Here, we further discuss the implications of our findings.

Keywords: Anaphase; DNA repair; mitosis; mutagenesis; SLX4; TopBP1; unscheduled DNA synthesis; 53BP1 nuclear bodies.