hMENA(11a), a hMENA isoform sending survival signals

Paola Trono; Francesca Di Modugno; Paola Nisticò

doi:10.1080/23723556.2015.1083648

hMENA(11a), a hMENA isoform sending survival signals

Mol Cell Oncol. 2015 Aug 27;3(2):e1083648. doi: 10.1080/23723556.2015.1083648. eCollection 2016 Mar.

Authors

Paola Trono¹, Francesca Di Modugno¹, Paola Nisticò¹

Affiliation

¹ Department of Research, Advanced Diagnostics and Technological Innovation, Regina Elena National Cancer Institute , Rome, Italy.

Abstract

Human MENA(11a) (hMENA(11a)), an epithelial-associated isoform of the actin binding protein enabled homolog (ENAH, also known as mammalian ENA [MENA]), is upregulated and phosphorylated following the activation of human epidermal growth factor receptor (HER) 1, HER2, and HER3. Here, we reveal a novel role of this isoform in sustaining cell survival and propose hMENA(11a) as a marker of HER3 activation and resistance to phosphatidylinositol-3-kinase inhibition therapies.

Keywords: Breast cancer; HER3; PI3K; oncogenic signaling; therapy resistance.