Divide and rule: The role of ubiquitination in inactivation of the ERK5-MAPK cascade

Katharina Schulenburg; Gabor Glatz; Attila Remenyi; Krishnaraj Rajalingam

doi:10.4161/23723548.2014.969170

Divide and rule: The role of ubiquitination in inactivation of the ERK5-MAPK cascade

Mol Cell Oncol. 2014 Nov 11;1(4):e969170. doi: 10.4161/23723548.2014.969170. eCollection 2014 Oct-Dec.

Authors

Katharina Schulenburg¹, Gabor Glatz², Attila Remenyi², Krishnaraj Rajalingam³

Affiliations

¹ Cell Death Signaling Group; Institute of Biochemistry II; Goethe University Medical School ; Frankfurt, Germany.
² Department of Biochemistry; Eötvös Loránd University; Budapest; Hungary Institute of Enzymology; Research Center for Natural Sciences Hungarian Academy of Sciences ; Budapest, Hungary.
³ Cell Death Signaling Group; Institute of Biochemistry II; Goethe University Medical School; Frankfurt, Germany; FZI; Molecular Signaling Unit; Institute for immunology; University Medical Center of the Johannes Gutenberg-University Mainz; Mainz, Germany.

Abstract

Recently, we revealed that ubiquitination of MEKK2 and MEKK3 by inhibitor of apoptosis proteins (IAPs) directly disrupts MEK5/ERK5 interaction and subsequently attenuates ERK5 activation. In addition, loss of XIAP promotes human myogenic differentiation in an ERK5-dependent manner. These results reveal another layer of MAPK regulation and a novel role for XIAP in controlling myogenic differentiation.

Keywords: ERK5; IAP; MAPK; PB1; XIAP; cIAP1; ubiquitin.