Park sleep: a non-motor dominant Parkinson's disease phenotype

BMJ Case Rep. 2016 Jun 9:2016:bcr2016215213. doi: 10.1136/bcr-2016-215213.

Abstract

A 69-year-old man was evaluated in our neurology department, for a presumed diagnosis of 'night-time seizures'; however, this diagnosis was quickly dismissed after the patient (and his wife) described how he 'acted out' and talked throughout his dreams, without any seizure-like activity. This problem had been present for ∼10 years. An EEG ruled out epilepsy. The patient also described a 10-year history of constipation, loss of smell and 'frequent collapses'. These symptoms fit in with the recently published criteria of 'prodromal Parkinson's Disease' and prompted a formal assessment for Parkinson's disease (PD). He had no tremor. A subtle festinating gait pattern and a 2-finger tremor in the right hand were noted. The diagnosis of PD was confirmed by a dopamine transporter scan. Clinically, this is one-Park sleep: rapid eye movement sleep behaviour disorder subtype-of 7 different non-motor dominant PD phenotypes recently described.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Clonazepam / therapeutic use
  • Humans
  • Levodopa / therapeutic use
  • Male
  • Parkinson Disease / drug therapy
  • Parkinson Disease / physiopathology*
  • Parkinson Disease / rehabilitation
  • REM Sleep Behavior Disorder / drug therapy
  • REM Sleep Behavior Disorder / etiology*
  • REM Sleep Behavior Disorder / physiopathology

Substances

  • Levodopa
  • Clonazepam