Red blood cell-derived microparticles: An overview

Maxwell Westerman; John B Porter

doi:10.1016/j.bcmd.2016.04.003

Red blood cell-derived microparticles: An overview

Blood Cells Mol Dis. 2016 Jul:59:134-9. doi: 10.1016/j.bcmd.2016.04.003. Epub 2016 Apr 13.

Authors

Maxwell Westerman¹, John B Porter²

Affiliations

¹ Mount Sinai Hospital, 1500 South California Avenue, Chicago, IL 60608, United States. Electronic address: max.westerman@sinai.org.
² Department of Haematology, University College London, 72 Huntley Street, London N I 4Pz, UK.

PMID: 27282583
DOI: 10.1016/j.bcmd.2016.04.003

Abstract

The red blood cell (RBC) is historically the original parent cell of microparticles (MPs). In this overview, we describe the discovery and the early history of red cell-derived microparticles (RMPs) and present an overview of the evolution of RMP. We report the formation, characteristics, effects of RMP and factors which may affect RMP evaluation. The review examines RMP derived from both normal and pathologic RBC. The pathologic RBC studies include sickle cell anemia (SCA), sickle cell trait (STr), thalassemia intermedia (TI), hereditary spherocytosis (HS), hereditary elliptocytosis (HE), hereditary stomatocytosis (HSt) and glucose-6-phosphate dehydrogenase deficiency (G6PD).

Keywords: Overview; Red blood cell-derived microparticles.

Publication types

Review

MeSH terms

Cell-Derived Microparticles / pathology*
Erythrocytes / cytology
Erythrocytes / pathology*
Hematologic Diseases / pathology
Humans