Distilling complexity to advance cardiac tissue engineering

Brenda M Ogle; Nenad Bursac; Ibrahim Domian; Ngan F Huang; Philippe Menasché; Charles E Murry; Beth Pruitt; Milica Radisic; Joseph C Wu; Sean M Wu; Jianyi Zhang; Wolfram-Hubertus Zimmermann; Gordana Vunjak-Novakovic

doi:10.1126/scitranslmed.aad2304

Distilling complexity to advance cardiac tissue engineering

Sci Transl Med. 2016 Jun 8;8(342):342ps13. doi: 10.1126/scitranslmed.aad2304.

Authors

Affiliations

¹ Department of Biomedical Engineering, Stem Cell Institute, Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.
² Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
³ Harvard Medical School and Harvard Stem Cell Institute, Boston, MA 02114, USA.
⁴ Department of Cardiothoracic Surgery, Stanford University, Stanford, CA 94305, USA. Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA.
⁵ Department of Cardiovascular Surgery, INSERM U 970, Hôpital Européen Georges Pompidou and University Paris Descartes, 75006 Paris, France.
⁶ Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, Departments of Pathology, Bioengineering, and Medicine, University of Washington, Seattle, WA 98109, USA.
⁷ Departments of Mechanical Engineering and, by courtesy, Molecular and Cellular Physiology and Bioengineering, Stanford University, Stanford, CA 94305, USA.
⁸ Institute of Biomaterials and Biomedical Engineering, Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario M5S 3G9, Canada.
⁹ Stanford Cardiovascular Institute and Departments of Medicine and Radiology, Stanford University School of Medicine, Stanford, CA 94305, USA.
¹⁰ Departments of Medicine and Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA.
¹¹ Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
¹² Institute of Pharmacology and Toxicology, University Medical Center, Georg-August University Göttingen and DZHK (German Center for Cardiovascular Research), partner site Göttingen, 37075 Göttingen, Germany.
¹³ Departments of Biomedical Engineering and Medicine, Columbia University, New York, NY 10032, USA. gv2131@columbia.edu.

Abstract

The promise of cardiac tissue engineering is in the ability to recapitulate in vitro the functional aspects of a healthy heart and disease pathology as well as to design replacement muscle for clinical therapy. Parts of this promise have been realized; others have not. In a meeting of scientists in this field, five central challenges or "big questions" were articulated that, if addressed, could substantially advance the current state of the art in modeling heart disease and realizing heart repair.

Publication types

Review
Research Support, N.I.H., Extramural

MeSH terms

Animals
Heart Diseases / metabolism
Humans
Myocardium / cytology*
Myocardium / metabolism
Myocytes, Cardiac / cytology
Tissue Engineering / methods*

Abstract

Publication types

MeSH terms

Grants and funding