Lanostane Triterpenes Isolated from Antrodia heteromorpha and Their Inhibitory Effects on RANKL-Induced Osteoclastogenesis

J Nat Prod. 2016 Jun 24;79(6):1689-93. doi: 10.1021/acs.jnatprod.6b00207. Epub 2016 Jun 7.

Abstract

Two new spiro-lanostane triterpenoids, antrolactones A and B (1 and 2), along with polyporenic acid C (3), were isolated from an EtOAc-soluble extract of Antrodia heteromorpha culture medium, and the chemical structures of the new compounds were elucidated by application of NMR, MS, and ECD spectroscopic techniques. All isolated compounds exhibited inhibitory effects on receptor activator of nuclear factor-kappaB ligand-induced osteoclastogenesis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antrodia / chemistry*
  • Lanosterol* / analogs & derivatives
  • Lanosterol* / chemistry
  • Lanosterol* / isolation & purification
  • Lanosterol* / pharmacology
  • Molecular Structure
  • Osteogenesis / drug effects*
  • RANK Ligand / pharmacology*
  • Triterpenes / chemistry
  • Triterpenes / isolation & purification*
  • Triterpenes / pharmacology*

Substances

  • RANK Ligand
  • TNFSF11 protein, human
  • Triterpenes
  • antrolactone A
  • antrolactone B
  • Lanosterol
  • polyporenic acid C