HLA-A, -B, -C, -DRB1 and -DQB1 allele and haplotype frequencies in a population of 432 healthy unrelated individuals from Albania

Genc Sulcebe; Erkena Shyti

doi:10.1016/j.humimm.2016.06.001

HLA-A, -B, -C, -DRB1 and -DQB1 allele and haplotype frequencies in a population of 432 healthy unrelated individuals from Albania

Hum Immunol. 2016 Aug;77(8):620-621. doi: 10.1016/j.humimm.2016.06.001. Epub 2016 Jun 2.

Authors

Genc Sulcebe¹, Erkena Shyti²

Affiliations

¹ Laboratory of Immunology and Histocompatibility, University of Medicine, Tirana and University Hospital Center "Mother Teresa", Tirana, Albania. Electronic address: gencsulcebe@gmail.com.
² Laboratory of Immunology and Histocompatibility, University of Medicine, Tirana and University Hospital Center "Mother Teresa", Tirana, Albania.

PMID: 27262454
DOI: 10.1016/j.humimm.2016.06.001

Abstract

This paper reports the HLA-A, -B, -C, -DRB1 and -DQB1 allele and haplotype polymorphism in a population of 432 healthy individuals from Albania. First-field HLA genotyping was performed by polymerase chain reaction sequence-specific priming and/or oligonucleotide methods. The data were analyzed statistically using gene counting and Arlequin software packages. No deviation from Hardy Weinberg Equilibrium was detected at any of the loci studied. The HLA genotypic data of the population sample reported here are available publicly in the Allele Frequencies Net Database and they can serve as a reference database for further HLA-based population genetics studies including the Albanian population.

Keywords: Albanian population; Anthropology population study; HLA; HLA alleles; HLA haplotypes.

MeSH terms

Albania
Base Sequence
Gene Frequency
Genotype
HLA-A Antigens / genetics*
HLA-B Antigens / genetics*
HLA-DQ beta-Chains / genetics*
HLA-DRB1 Chains / genetics*
Histocompatibility Testing
Humans
Molecular Sequence Data
Population Groups

Substances

HLA-A Antigens
HLA-B Antigens
HLA-DQ beta-Chains
HLA-DQB1 antigen
HLA-DRB1 Chains