Recent Advances in Egypt for Treatment of Talar Osteochondral Lesions

Foot Ankle Clin. 2016 Jun;21(2):405-20. doi: 10.1016/j.fcl.2016.01.010.

Abstract

Treatment of osteochondral defects (OCLs) of the talus is a challenging orthopedic surgery. Treatment of talar OCLs has evolved through the 3 "R" paradigm: reconstruction, repair, and replacement. This article highlights current state-of-the-art techniques and reviews recent advances in the literature about articular cartilage repair using various novel tissue engineering approaches, including various scaffolds, growth factors, and cell niches; which include chondrocytes and culture-expanded bone marrow-derived mesenchymal stem cells.

Keywords: Articular cartilage; Osteochondral lesions; Reconstruction; Repair; Talus; Tissue engineering.

Publication types

  • Review

MeSH terms

  • Bone Marrow Transplantation
  • Cartilage, Articular / pathology
  • Cartilage, Articular / surgery*
  • Chondrocytes
  • Egypt
  • Humans
  • Intercellular Signaling Peptides and Proteins
  • Mesenchymal Stem Cell Transplantation
  • Talus / surgery*
  • Tissue Engineering
  • Tissue Scaffolds
  • Transplantation, Autologous

Substances

  • Intercellular Signaling Peptides and Proteins