Synthesis of 6-phosphofructose aspartic acid and some related Amadori compounds

Alexandar L Hansen; Edward J Behrman

doi:10.1016/j.carres.2016.05.003

Synthesis of 6-phosphofructose aspartic acid and some related Amadori compounds

Carbohydr Res. 2016 Aug 5:431:1-5. doi: 10.1016/j.carres.2016.05.003. Epub 2016 May 14.

Authors

Alexandar L Hansen¹, Edward J Behrman²

Affiliations

¹ Campus Chemical Instrument Center, The Ohio State University, 496 W. 12th Avenue, Columbus, OH 43210, USA. Electronic address: Hansen.434@osu.edu.
² Department of Chemistry & Biochemistry, The Ohio State University, 484 W. 12th Avenue, Columbus, OH 43210, USA. Electronic address: Behrman.1@osu.edu.

Abstract

We describe the synthesis and characterization of 6-phosphofructose-aspartic acid, an intermediate in the metabolism of fructose-asparagine by Salmonella. We also report improved syntheses of fructose-asparagine itself and of fructose-aspartic acid.

Keywords: 6-Phosphofructose-aspartic acid; Amadori rearrangement; Fructose-asparagine; Fructose-aspartic acid; Salmonella.

MeSH terms

Asparagine / chemistry
Aspartic Acid / analogs & derivatives*
Aspartic Acid / chemistry
Fructosephosphates / chemical synthesis*
Fructosephosphates / chemistry
Molecular Structure

Substances

Fructosephosphates
Aspartic Acid
Asparagine

Grants and funding

R01 AI116119/AI/NIAID NIH HHS/United States