Syk kinase and Shp2 phosphatase inhibition cooperate to reduce FLT3-ITD-induced STAT5 activation and proliferation of acute myeloid leukemia

B M Richine; E L Virts; J D Bowling; B Ramdas; R Mali; R Naoye; Z Liu; Z-Y Zhang; H S Boswell; R Kapur; R J Chan

doi:10.1038/leu.2016.131

Syk kinase and Shp2 phosphatase inhibition cooperate to reduce FLT3-ITD-induced STAT5 activation and proliferation of acute myeloid leukemia

Leukemia. 2016 Oct;30(10):2094-2097. doi: 10.1038/leu.2016.131. Epub 2016 May 20.

Authors

B M Richine^{1

2}, E L Virts^{1

3}, J D Bowling¹, B Ramdas^{1

3}, R Mali^{1

3}, R Naoye¹, Z Liu⁴, Z-Y Zhang⁵, H S Boswell⁶, R Kapur^{1

2

3

7}, R J Chan^{1

2

3}

Affiliations

¹ Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA.
² Department of Medical & Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
³ Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.
⁴ Department of Biostatistics, Indiana University Richard M. Fairbanks School of Public Health, Indianapolis, IN, USA.
⁵ Department of Medicinal Chemistry & Molecular Pharmacology, Purdue College of Pharmacy, West Lafayette, IN, USA.
⁶ Department of Medicine, Division of Hematology/Oncology, Indiana University School of Medicine, Indianapolis, IN, USA.
⁷ Department of Biochemistry & Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.

No abstract available

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Cell Proliferation
Enzyme Inhibitors / pharmacology*
Humans
Leukemia, Myeloid, Acute / metabolism
Leukemia, Myeloid, Acute / pathology*
Protein Tyrosine Phosphatase, Non-Receptor Type 11 / antagonists & inhibitors*
STAT5 Transcription Factor / metabolism*
Sequence Homology, Amino Acid
Syk Kinase / antagonists & inhibitors*
fms-Like Tyrosine Kinase 3 / chemistry
fms-Like Tyrosine Kinase 3 / physiology*

Substances

Enzyme Inhibitors
STAT5 Transcription Factor
FLT3 protein, human
fms-Like Tyrosine Kinase 3
Syk Kinase
Protein Tyrosine Phosphatase, Non-Receptor Type 11

Publication types

MeSH terms

Substances

Grants and funding