Noncontact speckle-based optical sensor for detection of glucose concentration using magneto-optic effect

J Biomed Opt. 2016 Jun 1;21(6):65001. doi: 10.1117/1.JBO.21.6.065001.

Abstract

We experimentally verify a speckle-based technique for noncontact measurement of glucose concentration in the bloodstream. The final device is intended to be a single wristwatch-style device containing a laser, a camera, and an alternating current (ac) electromagnet generated by a solenoid. The experiments presented are performed in vitro as proof of the concept. When a glucose substance is inserted into a solenoid generating an ac magnetic field, it exhibits Faraday rotation, which affects the temporal changes of the secondary speckle pattern distributions. The temporal frequency resulting from the ac magnetic field was found to have a lock-in amplification role, which increased the observability of the relatively small magneto-optic effect. Experimental results to support the proposed concept are presented.

MeSH terms

  • Blood Chemical Analysis / instrumentation
  • Blood Chemical Analysis / methods*
  • Blood Glucose / analysis*
  • Humans
  • Lasers
  • Light
  • Magnets
  • Optics and Photonics*
  • Rotation

Substances

  • Blood Glucose