Transcriptome profiling of patient derived xenograft models established from pediatric acute myeloid leukemia patients confirm maintenance of FLT3-ITD mutation

Leuk Lymphoma. 2017 Jan;58(1):247-250. doi: 10.1080/10428194.2016.1187272. Epub 2016 Jun 1.

Authors

Christina D Drenberg^{1

2}, Daelynn R Buelow^{1

2}, Stanley B Pounds³, Yong-Dong Wang⁴, David Finkelstein⁴, Richard J Rahija⁵, Sheila A Shurtleff⁶, Jeffrey E Rubnitz⁶, Hiroto Inaba⁶, Tanja A Gruber⁶, Jeffery M Klco⁷, Sharyn D Baker^{1

2}

Affiliations

¹ a Division of Pharmaceutics, College of Pharmacy , The Ohio State University , Columbus , OH , USA.
² b Comprehensive Cancer Center , The Ohio State University , Columbus , OH , USA.
³ c Department of Biostatics , St. Jude Children's Research Hospital , Memphis , TN , USA.
⁴ d Department of Computational Biology , St. Jude Children's Research Hospital , Memphis , TN , USA.
⁵ e Animal Resource Center , St. Jude Children's Research Hospital , Memphis , TN , USA.
⁶ f Department of Pathology , St. Jude Children's Research Hospital , Memphis , TN , USA.
⁷ g Department of Oncology , St. Jude Children's Research Hospital , Memphis , TN , USA.

No abstract available

Publication types

Letter
Research Support, N.I.H., Extramural

MeSH terms

Acute Disease
Animals
Child
Cluster Analysis
Gene Expression Profiling*
Gene Expression Regulation, Leukemic*
Heterografts / metabolism*
Humans
Interleukin Receptor Common gamma Subunit / deficiency
Interleukin Receptor Common gamma Subunit / genetics
Leukemia, Myeloid / genetics*
Leukemia, Myeloid / pathology
Mice, Inbred NOD
Mice, Knockout
Mice, SCID
Mutation*
Oncogene Proteins, Fusion / genetics
Tandem Repeat Sequences / genetics
fms-Like Tyrosine Kinase 3 / genetics*

Substances

Il2rg protein, mouse
Interleukin Receptor Common gamma Subunit
NUP98-NSD1 protein, human
Oncogene Proteins, Fusion
FLT3 protein, human
fms-Like Tyrosine Kinase 3

Grants and funding