XPA: A key scaffold for human nucleotide excision repair

DNA Repair (Amst). 2016 Aug:44:123-135. doi: 10.1016/j.dnarep.2016.05.018. Epub 2016 May 20.

Abstract

Nucleotide excision repair (NER) is essential for removing many types of DNA lesions from the genome, yet the mechanisms of NER in humans remain poorly understood. This review summarizes our current understanding of the structure, biochemistry, interaction partners, mechanisms, and disease-associated mutations of one of the critical NER proteins, XPA.

Keywords: DNA repair; NER; XPA; Xeroderma pigmentosum..

Publication types

  • Review
  • Research Support, N.I.H., Extramural

MeSH terms

  • Amino Acid Sequence
  • Animals
  • DNA / chemistry
  • DNA / metabolism*
  • DNA Damage
  • DNA Repair*
  • Humans
  • Models, Molecular
  • Mutation
  • Protein Binding
  • Protein Domains
  • Protein Interaction Mapping
  • Protein Structure, Secondary
  • Severity of Illness Index
  • Xeroderma Pigmentosum / genetics*
  • Xeroderma Pigmentosum / metabolism
  • Xeroderma Pigmentosum / pathology
  • Xeroderma Pigmentosum Group A Protein / chemistry
  • Xeroderma Pigmentosum Group A Protein / genetics
  • Xeroderma Pigmentosum Group A Protein / metabolism*

Substances

  • XPA protein, human
  • Xeroderma Pigmentosum Group A Protein
  • DNA