New Casbane and Cembrane Diterpenoids from an Okinawan Soft Coral, Lobophytum sp

Molecules. 2016 May 23;21(5):679. doi: 10.3390/molecules21050679.

Abstract

A new rare casbane-type diterpenoid 1 and two new cembrane diterpenoids 2, 3 were isolated from an Okinawan soft coral, Lobophytum sp., together with four known cembrane diterpenoids 4-7. Their structures were elucidated by extensive analysis of spectroscopic data (1D and 2D NMR, IR, and MS) and a molecular modeling study. The new isolates showed weak anti-bacterial activity, mild cytotoxicity against HCT116 cells, and anti-inflammatory effect in LPS/IFN-γ-stimulated RAW 264.7 macrophage cells.

Keywords: HCT 116 cells; anti-inflammatory; antibacterial; casbane; cembrane; cytotoxicity.

MeSH terms

  • Animals
  • Anthozoa / chemistry*
  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / chemistry
  • Cell Proliferation / drug effects*
  • Diterpenes / administration & dosage
  • Diterpenes / chemistry*
  • Diterpenes / isolation & purification
  • HCT116 Cells
  • Humans
  • Infections / drug therapy
  • Infections / microbiology
  • Inflammation / chemically induced
  • Inflammation / drug therapy*
  • Lipopolysaccharides / toxicity
  • Mice
  • Molecular Structure
  • RAW 264.7 Cells / drug effects

Substances

  • Anti-Bacterial Agents
  • Diterpenes
  • Lipopolysaccharides