[Pathophysiology of preeclampsia]

Edouard Lecarpentier; Thierry Fournier; Jean Guibourdenche; Vassilis Tsatsaris

doi:10.1016/j.lpm.2016.04.016

[Pathophysiology of preeclampsia]

Presse Med. 2016 Jul-Aug;45(7-8 Pt 1):631-7. doi: 10.1016/j.lpm.2016.04.016. Epub 2016 May 20.

[Article in French]

Authors

Edouard Lecarpentier¹, Thierry Fournier², Jean Guibourdenche¹, Vassilis Tsatsaris³

Affiliations

¹ Assistance publique-Hôpitaux de Paris, centre hospitalier universitaire Cochin Broca-Hôtel-Dieu, université Paris-Descartes, 75014 Paris, France; Inserm, UMR-S 1139, 75006 Paris, France; DHU risques et grossesse, 75014 Paris, France; Fondation PremUP, 75014 Paris, France.
² Inserm, UMR-S 1139, 75006 Paris, France; DHU risques et grossesse, 75014 Paris, France; Fondation PremUP, 75014 Paris, France.
³ Assistance publique-Hôpitaux de Paris, centre hospitalier universitaire Cochin Broca-Hôtel-Dieu, université Paris-Descartes, 75014 Paris, France; Inserm, UMR-S 1139, 75006 Paris, France; DHU risques et grossesse, 75014 Paris, France; Fondation PremUP, 75014 Paris, France. Electronic address: vassilis.tsatsaris@cch.aphp.fr.

PMID: 27217262
DOI: 10.1016/j.lpm.2016.04.016

Abstract

Preeclampsia is a hypertensive disease of pregnancy due to abnormal utero-placental circulation. Hypoperfusion of the placenta and hypoxia/reoxygenation of the intervillous space are responsible of placental dysfunction. Trophoblastic factors are released in the maternal circulation and are responsible of the maternal endothelial dysfunction that characterize preeclampsia. Among those factors, the PlGF/sFlt-1 couple plays a major pathophysiologic role.

MeSH terms

Female
Humans
Placenta / physiopathology
Pre-Eclampsia / physiopathology*
Pregnancy
Uterus / blood supply