Abstract
Different inocula of Trichoderma longibrachiatum were tested in a murine model, and only the highest one (1 × 10(7) CFU/animal) killed all of the mice at day 15 postinfection, with spleen and liver the most affected organs. The efficacies of amphotericin B deoxycholate, liposomal amphotericin B, voriconazole, and micafungin were evaluated in the same model, with very poor results. Our study demonstrated the low virulence but high resistance to antifungal compounds of this fungus.
Copyright © 2016, American Society for Microbiology. All Rights Reserved.
MeSH terms
-
Amphotericin B / therapeutic use
-
Animals
-
Antifungal Agents / therapeutic use*
-
Deoxycholic Acid / therapeutic use
-
Drug Combinations
-
Echinocandins / therapeutic use
-
Lipopeptides / therapeutic use
-
Liver / microbiology
-
Male
-
Micafungin
-
Mice
-
Mycoses / drug therapy
-
Mycoses / microbiology
-
Spleen / microbiology
-
Trichoderma / drug effects*
-
Trichoderma / pathogenicity*
-
Virulence / drug effects
Substances
-
Antifungal Agents
-
Drug Combinations
-
Echinocandins
-
Lipopeptides
-
liposomal amphotericin B
-
Deoxycholic Acid
-
Amphotericin B
-
amphotericin B, deoxycholate drug combination
-
Micafungin