Virulence and Experimental Treatment of Trichoderma longibrachiatum, a Fungus Refractory to Treatment

Antimicrob Agents Chemother. 2016 Jul 22;60(8):5029-32. doi: 10.1128/AAC.00373-16. Print 2016 Aug.

Abstract

Different inocula of Trichoderma longibrachiatum were tested in a murine model, and only the highest one (1 × 10(7) CFU/animal) killed all of the mice at day 15 postinfection, with spleen and liver the most affected organs. The efficacies of amphotericin B deoxycholate, liposomal amphotericin B, voriconazole, and micafungin were evaluated in the same model, with very poor results. Our study demonstrated the low virulence but high resistance to antifungal compounds of this fungus.

MeSH terms

  • Amphotericin B / therapeutic use
  • Animals
  • Antifungal Agents / therapeutic use*
  • Deoxycholic Acid / therapeutic use
  • Drug Combinations
  • Echinocandins / therapeutic use
  • Lipopeptides / therapeutic use
  • Liver / microbiology
  • Male
  • Micafungin
  • Mice
  • Mycoses / drug therapy
  • Mycoses / microbiology
  • Spleen / microbiology
  • Trichoderma / drug effects*
  • Trichoderma / pathogenicity*
  • Virulence / drug effects

Substances

  • Antifungal Agents
  • Drug Combinations
  • Echinocandins
  • Lipopeptides
  • liposomal amphotericin B
  • Deoxycholic Acid
  • Amphotericin B
  • amphotericin B, deoxycholate drug combination
  • Micafungin