The differential frequency of Lineage(-)CRTH2(-)CD45(+)NKp44(-)CD117(-)CD127(+)ILC subset in the inflamed terminal ileum of patients with Crohn's disease

Cell Immunol. 2016 Jun-Jul:304-305:63-8. doi: 10.1016/j.cellimm.2016.05.001. Epub 2016 May 9.

Abstract

Deregulation of various components of the immune system has been reported in the inflamed gut of Crohn's disease (CD) patients. Innate lymphoid cells (ILCs) are novel innate effector lymphocytes which can rapidly respond to danger signals, from invading pathogens or tissue damage, to maintain homeostasis, especially along the mucosal surfaces. The purpose of this study is to compare composition of the intestinal ILCs subsets of CD patients with differential inflammatory conditions of the terminal ileum, which are marked by distinct histological appearances and mucosal profiles of cytokines. We observed alterations in the frequency of Lineage(-)CRTH2(-)CD45(+)NKp44(-)CD117(-)CD127(+)ILC subset in the inflamed terminal ileum.

Keywords: CD; ILC frequency; Terminal ileum.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Cell Lineage
  • Crohn Disease / immunology*
  • Humans
  • Ileum / pathology*
  • Immunity, Innate*
  • Immunophenotyping
  • Inflammation / immunology*
  • Interleukin-7 Receptor alpha Subunit / metabolism
  • Intestinal Mucosa / immunology*
  • Leukocyte Common Antigens / metabolism
  • Lymphocyte Subsets / immunology*
  • Lymphocytes / immunology*
  • Male
  • Middle Aged
  • Natural Cytotoxicity Triggering Receptor 2 / metabolism
  • Proto-Oncogene Proteins c-kit / metabolism
  • Receptors, Immunologic / metabolism
  • Receptors, Prostaglandin / metabolism

Substances

  • Interleukin-7 Receptor alpha Subunit
  • NCR2 protein, human
  • Natural Cytotoxicity Triggering Receptor 2
  • Receptors, Immunologic
  • Receptors, Prostaglandin
  • Proto-Oncogene Proteins c-kit
  • Leukocyte Common Antigens
  • prostaglandin D2 receptor