The histological variants of liposarcoma: predictive MRI findings with prognostic implications, management, follow-up, and differential diagnosis

Skeletal Radiol. 2016 Sep;45(9):1193-204. doi: 10.1007/s00256-016-2409-4. Epub 2016 May 21.

Abstract

Liposarcoma is the single most common soft tissue sarcoma accounting for up to 35 % of sarcomas. It represents a histologically diverse group of soft tissue tumors that demonstrate a wide range of imaging appearances with varied behavior patterns. Correspondingly, more aggressive histological subtypes often require management that includes a combination of surgery, chemotherapy, and radiation therapy. Distinguishing among liposarcoma subtypes has important therapeutic and prognostic implications. In this manuscript, we review the liposarcoma subtypes and their histologic and MRI findings, prognostic implications, and differential diagnostic considerations.

Keywords: Atypical lipomatous tumor; Follow-up; Liposarcoma; MRI; Management; Surveillance.

Publication types

  • Review

MeSH terms

  • Diagnosis, Differential
  • Follow-Up Studies
  • Humans
  • Liposarcoma / diagnosis*
  • Liposarcoma / pathology*
  • Liposarcoma / therapy*
  • Magnetic Resonance Imaging
  • Prognosis