The Incredible ULKs: Autophagy and Beyond

Yan G Zhao; Hong Zhang

doi:10.1016/j.molcel.2016.05.005

The Incredible ULKs: Autophagy and Beyond

Mol Cell. 2016 May 19;62(4):475-6. doi: 10.1016/j.molcel.2016.05.005.

Authors

Yan G Zhao¹, Hong Zhang²

Affiliations

¹ National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, P.R. China.
² National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, P.R. China. Electronic address: hongzhang@sun5.ibp.ac.cn.

PMID: 27203174
DOI: 10.1016/j.molcel.2016.05.005

Abstract

Atg1 integrates nutrient status and autophagy. In this issue, Joo et al. (2016) reveal that the mammalian Atg1 homologs ULK1/2 are dispensable for neuronal basal autophagy. ULK1/2 phosphorylate SEC16A and regulate ER export, expanding the autophagy-independent functions of autophagy proteins.

Publication types

Comment

MeSH terms

Animals
Autophagy*
Autophagy-Related Protein-1 Homolog
Humans
Mammals*

Substances

Autophagy-Related Protein-1 Homolog