Defective Autophagy Initiates Malignant Transformation

Mol Cell. 2016 May 19;62(4):473-4. doi: 10.1016/j.molcel.2016.05.001.

Abstract

In this issue of Molecular Cell, Park et al. (2016) elegantly demonstrate that a partial defect in autophagy supports malignant transformation as it favors the production of genotoxic reactive oxygen species by mitochondria.

Keywords: U2AF1(S34F); alternative splicing; autophagic flux; mutational rate; myelodysplastic syndrome; regulated cell death.

Publication types

  • Comment

MeSH terms

  • Autophagy*
  • Cell Transformation, Neoplastic
  • DNA Damage
  • Mitochondria
  • Reactive Oxygen Species*

Substances

  • Reactive Oxygen Species