Quinine unbound concentration is the best marker for therapeutic drug monitoring

Therapie. 2016 Oct;71(5):487-489. doi: 10.1016/j.therap.2016.02.032. Epub 2016 Apr 11.

¹ Pharmacokinetics and toxicology laboratory, federative institute of biology, Purpan university hospital, 31000 Toulouse, France.
² Infectious diseases department, Purpan university hospital, 31000 Toulouse, France.
³ Parasitology laboratory, federative institute of biology, Purpan university hospital, 31000 Toulouse, France.
⁴ EA4553 pharmacology and pharmacogenetic laboratory, university institute of cancer (Oncopôle), 31000 Toulouse, France.
⁵ UMR1331-TOXALIM, Toulouse veterinary school, 31000 Toulouse, France.
⁶ Pharmacokinetics and toxicology laboratory, federative institute of biology, Purpan university hospital, 31000 Toulouse, France; EA4553 pharmacology and pharmacogenetic laboratory, university institute of cancer (Oncopôle), 31000 Toulouse, France. Electronic address: gandia.p@chu-toulouse.fr.

Abstract

Quinine monitoring should be based on unbound concentration due to variable unbound fraction in malaria patients.

Keywords: Fraction libre; Quinine; Suivi pharmacologique thérapeutique; Therapeutic drug monitoring; Unbound fraction.