GEE: An Informatics Tool for Gene Expression Data Explore

Healthc Inform Res. 2016 Apr;22(2):81-8. doi: 10.4258/hir.2016.22.2.81. Epub 2016 Apr 30.

Abstract

Objectives: Major public high-throughput functional genomic data repositories, including the Gene Expression Omnibus (GEO) and ArrayExpress have rapidly expanded. As a result, a large number of diverse high-throughput functional genomic data retrieval systems have been developed. However, high-throughput functional genomic data retrieval remains challenging.

Methods: We developed Gene Expression data Explore (GEE), the first powerful, flexible web and mobile search application for searching whole-genome epigenetic data and microarray data in public databases, such as GEO and ArrayExpress.

Results: GEE provides an elaborate, convenient interface of query generation competences not available via various high-throughput functional genomic data retrieval systems, including GEO, ArrayExpress, and Atlas. In particular, GEE provides a suitable query generator using eVOC, the Experimental Factor Ontology (EFO), which is well represented with a variety of high-throughput functional genomic data experimental conditions. In addition, GEE provides an experimental design query constructor (EDQC), which provides elaborate retrieval filter conditions when the user designs real experiments.

Conclusions: The web version of GEE is available at http://www.snubi.org/software/gee, and its app version is available from the Apple App Store.

Keywords: Microarray Analysis; Mobile Applications; RNA Sequence; Search Engine.