Abstract
Mycochemical study of the mushroom Gymnopus fusipes led to the discovery of two new cyclopeptides. The two compounds, named as gymnopeptides A and B, are unprecedented highly N-methylated cyclic octadecapeptides. Detailed spectroscopic studies, Marfey's analysis, and a preliminary molecular modeling study suggested that both are natural cyclic β hairpins. The isolated compounds exhibited striking antiproliferative activity on several human cancer cell lines, with nanomolar IC50 values.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Agaricales / chemistry*
-
Antineoplastic Agents / chemistry*
-
Antineoplastic Agents / isolation & purification
-
Antineoplastic Agents / pharmacology
-
Drug Screening Assays, Antitumor
-
HeLa Cells
-
Humans
-
Inhibitory Concentration 50
-
MCF-7 Cells
-
Oligopeptides / chemistry*
-
Oligopeptides / isolation & purification
-
Oligopeptides / pharmacology
-
Peptides, Cyclic / chemistry*
-
Peptides, Cyclic / isolation & purification
-
Peptides, Cyclic / pharmacology
Substances
-
Antineoplastic Agents
-
Oligopeptides
-
Peptides, Cyclic