Chronic Anterior Uveitis in Children

Ocul Immunol Inflamm. 2016 Aug;24(4):392-6. doi: 10.3109/09273948.2016.1167223. Epub 2016 May 18.

Abstract

Purpose: To describe the visual prognosis and remission rate of chronic anterior uveitis in pediatric patients.

Methods: A retrospective case series of children with chronic anterior uveitis treated in the University of Buenos Aires. Juvenile idiopathic arthritis was defined according to the International League of Associations for Rheumatology criteria. Uveitis remission was defined according to SUN criteria.

Results: There were 35 pediatric patients (61 eyes), mean age of uveitis onset was 7.69 ± 3 years, 60% were females and 74% had bilateral disease, median follow-up was 60 months (range: 12-192 months). JIA was more frequent in females (80.95 vs 21.43; p<0.0001) and oligoarthritis was the most common form. Remission rate was higher in males (HR = 4.99; 95% CI = 1.16-21.51; p = 0.031). More than 40 eyes remained with the same BCVA at 1 year of follow-up.

Conclusions: Although remission was not common and only occurred after long-term follow-up, visual prognosis was good Received 30 August 2015; revised 6 March 2016; accepted 14 March 2016; published online 18 May 2016.

Keywords: Anterior uveitis; child; males; prognosis; remission.

MeSH terms

  • Adolescent
  • Arthritis, Juvenile / diagnosis
  • Child
  • Child, Preschool
  • Chronic Disease
  • Female
  • Follow-Up Studies
  • Glucocorticoids / therapeutic use
  • HLA-B27 Antigen / immunology
  • Humans
  • Male
  • Prognosis
  • Retrospective Studies
  • Uveitis, Anterior / diagnosis*
  • Uveitis, Anterior / drug therapy
  • Uveitis, Anterior / physiopathology
  • Visual Acuity / physiology*

Substances

  • Glucocorticoids
  • HLA-B27 Antigen