Hollow Structure Improved Anti-Cancer Immunity of Mesoporous Silica Nanospheres In Vivo

Small. 2016 Jul;12(26):3510-5. doi: 10.1002/smll.201600677. Epub 2016 May 18.

Abstract

Hollow and non-hollow mesoporous silica nanospheres are synthesized and used for cancer vaccine adjuvants. The hollow structure of mesoporous silica nanospheres significantly promote cellular uptake of a model cancer antigen by macrophage-like cells in vitro, improve anti-cancer immunity, CD4(+) and CD8(+) T cell populations in splenocytes of mice in vivo.

Keywords: cancer immunoadjuvant; hollow structures; mesoporous silica nanospheres.

MeSH terms

  • Adjuvants, Immunologic / adverse effects
  • Adjuvants, Immunologic / chemistry*
  • Animals
  • Cancer Vaccines / administration & dosage
  • Cancer Vaccines / chemistry
  • Cell Survival / drug effects
  • Mice
  • Microscopy, Electrochemical, Scanning
  • Microscopy, Electron, Transmission
  • NIH 3T3 Cells
  • Nanospheres / adverse effects
  • Nanospheres / chemistry*
  • Nanospheres / ultrastructure
  • Porosity
  • Silicon Dioxide / chemistry*

Substances

  • Adjuvants, Immunologic
  • Cancer Vaccines
  • Silicon Dioxide