Human Adaptive Natural Killer Cells: Beyond NKG2C

Trends Immunol. 2016 Jun;37(6):351-353. doi: 10.1016/j.it.2016.05.001. Epub 2016 May 11.

Abstract

Paradigm-shifting studies have identified NKG2C(+) adaptive natural killer (NK) cells in individuals infected with cytomegalovirus. Recently in Cell Reports, Liu et al. demonstrate that NKG2C(-/-) HCMV(+) individuals also generate adaptive NK cells, and reveal CD2 as a major co-stimulatory receptor for these NK cells specialized to respond via FcγRIIIa/CD16.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Adaptive Immunity*
  • CD2 Antigens / metabolism*
  • Cytomegalovirus / immunology*
  • Cytomegalovirus Infections / immunology*
  • Humans
  • Immunity, Innate
  • Immunologic Memory
  • Interleukin-12 / metabolism
  • Interleukin-15 / metabolism
  • Interleukin-18 / metabolism
  • Killer Cells, Natural / immunology*
  • Lymphocyte Activation
  • NK Cell Lectin-Like Receptor Subfamily C / metabolism*
  • Receptors, IgG / metabolism*

Substances

  • CD2 Antigens
  • FCGR3A protein, human
  • Interleukin-15
  • Interleukin-18
  • KLRC2 protein, human
  • NK Cell Lectin-Like Receptor Subfamily C
  • Receptors, IgG
  • Interleukin-12