HLA-C Downmodulation by HIV-1 Vpu

Edward Barker; David T Evans

doi:10.1016/j.chom.2016.04.023

HLA-C Downmodulation by HIV-1 Vpu

Cell Host Microbe. 2016 May 11;19(5):570-1. doi: 10.1016/j.chom.2016.04.023.

Authors

Edward Barker¹, David T Evans²

Affiliations

¹ Department of Immunology and Microbiology, Rush University Medical Center, 1735 W. Harrison Street, 620 Cohn Building, Chicago, IL 60612, USA. Electronic address: edward_barker@rush.edu.
² Pathology & Laboratory Medicine, University of Wisconsin, AIDS Vaccine Research Laboratory 585 Science Drive, Madison, WI 53711, USA.

PMID: 27173922
DOI: 10.1016/j.chom.2016.04.023

Abstract

It is widely held that HIV-1 Nef downmodulates HLA-A and -B to protect infected cells from CD8(+) T cells but leaves HLA-C on the cell surface to inhibit NK cells. In this issue of Cell Host & Microbe, Apps et al. (2016) revise this model by showing that the Vpu protein of primary HIV-1 isolates downmodulate HLA-C.

Publication types

Comment

MeSH terms

CD8-Positive T-Lymphocytes
Down-Regulation
HIV-1*
HLA-C Antigens
Humans
nef Gene Products, Human Immunodeficiency Virus / genetics*

Substances

HLA-C Antigens
nef Gene Products, Human Immunodeficiency Virus

Abstract

Publication types

MeSH terms

Substances

Grants and funding