A suitable planting pattern and irrigation strategy are essential for optimizing winter wheat yield and water use efficiency (WUE). The study aimed to evaluate the impact of planting pattern and irrigation frequency on grain yield and WUE of winter wheat. During the 2013-2014 and 2014-2015 winter wheat growing seasons in the North China Plain, the effects of planting patterns and irrigation frequencies were determined on tiller number, grain yield, and WUE. The two planting patterns tested were wide-precision and conventional-cultivation. Each planting pattern had three irrigation regimes: irrigation (120 mm) at the jointing stage; irrigation (60 mm) at both the jointing and heading stages; and irrigation (40 mm) at the jointing, heading, and milking stages. In our study, tiller number was significantly higher in the wide-precision planting pattern than in the conventional-cultivation planting pattern. Additionally, the highest grain yields and WUE were observed when irrigation was applied at the jointing stage (120 mm) or at the jointing and heading stages (60 mm each) in the wide-precision planting pattern. These results could be attributed to higher tiller numbers as well as reduced water consumption due to reduced irrigation frequency. In both growing seasons, applying 60 mm of water at jointing and heading stages resulted in the highest grain yield among the treatments. Based on our results, for winter wheat production in semi-humid regions, we recommend a wide-precision planting pattern with irrigation (60 mm) at both the jointing and heading stages.