First presentation of Addison's disease as hyperkalaemia in acute kidney injury

BMJ Case Rep. 2016 May 11:2016:bcr2015213375. doi: 10.1136/bcr-2015-213375.

Abstract

Addison's disease is a rare endocrine disorder that frequently presents with non-specific symptoms, but may deteriorate rapidly into life-threatening Addisonian crisis if left untreated. Diagnosis can be difficult in patients without a suggestive medical history. We describe a case of a 37-year-old man who was admitted with acute kidney injury and hyperkalaemia, resistant to treatment with insulin/dextrose and calcium gluconate. On clinical examination, he was found to be hyperpigmented; a subsequent random serum cortisol of 49 nmol/L affirmed the preliminary diagnosis of Addison's disease. The patient's hyperkalaemia improved on treatment with hydrocortisone, and a follow-up morning adrenocorticotropic hormone of 1051 ng/L confirmed the diagnosis.

Publication types

  • Case Reports

MeSH terms

  • Acute Kidney Injury / drug therapy
  • Acute Kidney Injury / etiology*
  • Addison Disease / diagnosis*
  • Addison Disease / drug therapy
  • Adult
  • Diagnosis, Differential
  • Humans
  • Hydrocortisone / administration & dosage
  • Hydrocortisone / therapeutic use
  • Hyperkalemia / drug therapy
  • Hyperkalemia / etiology*
  • Male
  • Treatment Outcome

Substances

  • Hydrocortisone