Influence of Lipophilicity on the Toxicity of Bisphenol A and Phthalates to Aquatic Organisms

Bull Environ Contam Toxicol. 2016 Jul;97(1):4-10. doi: 10.1007/s00128-016-1812-9. Epub 2016 May 12.

Abstract

Bisphenol A (BPA) and phthalates are among the most popular plasticizers used today and have been reported ubiquitously in surface water, ground water, and sediment. For aquatic organisms, BPA was the most toxic (96 h LC50s) to aquatic invertebrates (0.96-2.70 mg/L) and less toxic to fish (6.8-17.9 mg/L). The toxicity of BPA to amphibians differed among developmental stages, with embryos having an LC50 of 4.6-6.8 mg/L and juveniles 0.50-1.4 mg/L. The toxicity of phthalates is affected by aromatic ring substitution, alkyl chain length, and metabolism. The toxicity (96 h LC50s) of phthalates was similar to aquatic invertebrates (0.46-377 mg/L) and fish (0.48-121 mg/L). In general, the toxicity of phthalates appears to be highest around a log KOW of 6, which corresponds to the highest potential for bioconcentration and bioaccumulation. In conclusion, the lipophilicity of BPA and phthalates influence their toxicity to aquatic species.

Keywords: Aquatic species; Bisphenol A; Lethal concentration; Phthalate; Toxicity.

Publication types

  • Review

MeSH terms

  • Animals
  • Aquatic Organisms
  • Benzhydryl Compounds / toxicity*
  • Fishes
  • Invertebrates
  • Lethal Dose 50
  • Phenols / toxicity*
  • Phthalic Acids / toxicity*
  • Plasticizers / toxicity*

Substances

  • Benzhydryl Compounds
  • Phenols
  • Phthalic Acids
  • Plasticizers
  • phthalic acid
  • bisphenol A