Ionone Derivatives from the Mycelium of Phellinus linteus and the Inhibitory Effect on Activated Rat Hepatic Stellate Cells

Shiow-Chyn Huang; Ping-Chung Kuo; Hsin-Yi Hung; Tai-Long Pan; Fu-An Chen; Tian-Shung Wu

doi:10.3390/ijms17050681

Ionone Derivatives from the Mycelium of Phellinus linteus and the Inhibitory Effect on Activated Rat Hepatic Stellate Cells

Int J Mol Sci. 2016 May 6;17(5):681. doi: 10.3390/ijms17050681.

Authors

Shiow-Chyn Huang¹, Ping-Chung Kuo², Hsin-Yi Hung³, Tai-Long Pan^{4

5

6}, Fu-An Chen⁷, Tian-Shung Wu^{8

9}

Affiliations

¹ Department of Pharmacy, Chia-Nan University of Pharmacy and Science, Tainan 717, Taiwan. schuang@mail.cnu.edu.tw.
² School of Pharmacy, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan. z10502016@email.ncku.edu.tw.
³ School of Pharmacy, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan. z10308005@email.ncku.edu.tw.
⁴ School of Traditional Chinese Medicine, Chang Gung University, Taoyuan 333, Taiwan. pan@mail.cgu.edu.tw.
⁵ Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan. pan@mail.cgu.edu.tw.
⁶ Liver Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan. pan@mail.cgu.edu.tw.
⁷ Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 907, Taiwan. fachen@tajen.edu.tw.
⁸ School of Pharmacy, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan. tswu@mail.ncku.edu.tw.
⁹ Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 907, Taiwan. tswu@mail.ncku.edu.tw.

Abstract

Three new γ-ionylideneacetic acid derivatives, phellinulins A-C (1-3), were characterized from the mycelium extract of Phellinus linteus. The chemical structures were established based on the spectroscopic analysis. In addition, phellinulin A (1) was subjected to the examination of effects on activated rat hepatic stellate cells and exhibited significant inhibition of hepatic fibrosis.

Keywords: Phellinus linteus; fungus; hepatic fibrosis; ionone; phellinulin.

Publication types

Letter

MeSH terms

Abscisic Acid / analogs & derivatives
Abscisic Acid / chemistry
Animals
Basidiomycota / chemistry
Hep G2 Cells
Hepatic Stellate Cells / drug effects*
Humans
Norisoprenoids / chemistry
Norisoprenoids / pharmacology
Phellinus
Plant Extracts / chemistry*
Plant Extracts / pharmacology
Rats

Substances

Norisoprenoids
Phellinus linteus extract
Plant Extracts
gamma-ionylideneacetic acid
Abscisic Acid