Prenatally Diagnosed Cases of Binder Phenotype Complicated by Respiratory Distress in the Immediate Postnatal Period

Yair J Blumenfeld; Alexis S Davis; Susan R Hintz; Kristina Milan; Anna H Messner; Richard A Barth; Louanne Hudgins; Jane Chueh; Margaret Homeyer; Jonathan A Bernstein; Gregory Enns; Paldeep Atwal; Melanie Manning

doi:10.7863/ultra.15.02050

Prenatally Diagnosed Cases of Binder Phenotype Complicated by Respiratory Distress in the Immediate Postnatal Period

J Ultrasound Med. 2016 Jun;35(6):1353-8. doi: 10.7863/ultra.15.02050. Epub 2016 May 9.

Authors

Affiliations

¹ Departments of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Stanford University School of Medicine, Stanford, California USACenter for Fetal and Maternal Health, Lucile Packard Children's Hospital Stanford, Palo Alto, California USA yairb@stanford.edu.
² Departments of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Stanford, California USACenter for Fetal and Maternal Health, Lucile Packard Children's Hospital Stanford, Palo Alto, California USA.
³ Departments of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Stanford University School of Medicine, Stanford, California USACenter for Fetal and Maternal Health, Lucile Packard Children's Hospital Stanford, Palo Alto, California USA.
⁴ Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, California USA.
⁵ Department of Radiology, Stanford University School of Medicine, Stanford, California USACenter for Fetal and Maternal Health, Lucile Packard Children's Hospital Stanford, Palo Alto, California USA.
⁶ Department of Pediatrics, Division of Medical Genetics, Stanford University School of Medicine, Stanford, California USACenter for Fetal and Maternal Health, Lucile Packard Children's Hospital Stanford, Palo Alto, California USA.
⁷ Department of Pediatrics, Division of Medical Genetics, Stanford University School of Medicine, Stanford, California USA.
⁸ Department of Pediatrics, Division of Medical Genetics, Stanford University School of Medicine, Stanford, California USADepartment of Pathology, Stanford University School of Medicine, Stanford, California USA.

PMID: 27162279
DOI: 10.7863/ultra.15.02050

Abstract

Binder phenotype, or maxillonasal dysostosis, is a distinctive pattern of facial development characterized by a short nose with a flat nasal bridge, an acute nasolabial angle, a short columella, a convex upper lip, and class III malocclusion. We report 3 cases of prenatally diagnosed Binder phenotype associated with perinatal respiratory impairment.

Keywords: Binder phenotype; magnetic resonance imaging; obstetric ultrasound; prenatal diagnosis; respiratory distress; sonography.

Publication types

Case Reports

MeSH terms

Adult
Diagnosis, Differential
Female
Humans
Infant, Newborn
Magnetic Resonance Imaging
Male
Maxillofacial Abnormalities / complications*
Maxillofacial Abnormalities / diagnostic imaging*
Pregnancy
Prenatal Diagnosis / methods*
Respiratory Insufficiency / complications*
Ultrasonography, Prenatal

Supplementary concepts

Maxillonasal dysplasia, Binder type