GPER-novel membrane oestrogen receptor

Clin Sci (Lond). 2016 Jun 1;130(12):1005-16. doi: 10.1042/CS20160114.

Abstract

The recent discovery of the G protein-coupled oestrogen receptor (GPER) presents new challenges and opportunities for understanding the physiology, pathophysiology and pharmacology of many diseases. This review will focus on the expression and function of GPER in hypertension, kidney disease, atherosclerosis, vascular remodelling, heart failure, reproduction, metabolic disorders, cancer, environmental health and menopause. Furthermore, this review will highlight the potential of GPER as a therapeutic target.

Keywords: GPR30; cancer; cardiovascular; menopause; metabolism; reproduction.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Estrogens / metabolism*
  • Humans
  • Hypertension / metabolism*
  • Kidney Diseases / metabolism*
  • Receptors, Estrogen / metabolism*
  • Receptors, G-Protein-Coupled / metabolism*

Substances

  • Estrogens
  • GPER1 protein, human
  • Receptors, Estrogen
  • Receptors, G-Protein-Coupled