Cancer-Targeted Nanotheranostics: Recent Advances and Perspectives

Small. 2016 Sep;12(36):4936-4954. doi: 10.1002/smll.201600635. Epub 2016 May 6.

Abstract

Cancer-targeted nanotechnology is experiencing the trend of finding new materials with multiple functions for imaging and therapeutic applications. With the rapid development of the related fields, there exists a large number of reports regarding theranostic nanomedicine, decreasing the gap between cancer diagnosis and treatment with minimized separate comprehensions. In order to present an overview on the cancer-targeted nanotheranostics, we first describe their essential building blocks, including platforms, therapeutic agents and imaging agents, and then the recently rapidly developed multimodal theranostic systems. Finally we discuss the major challenges and the perspectives of future development of nanotheranostics toward clinical translations and personalized nanomedicine.

Keywords: imaging; nanomaterials; nanomedicine; theranostics; therapy.

Publication types

  • Review

MeSH terms

  • Animals
  • Diagnostic Imaging
  • Humans
  • Multimodal Imaging
  • Nanostructures
  • Neoplasms / pathology
  • Neoplasms / therapy*
  • Theranostic Nanomedicine / methods*