Targeting autophagy in antitumor agent design: furthering the 'lysosomal love' strategy

Future Med Chem. 2016 May;8(7):727-9. doi: 10.4155/fmc-2016-0066. Epub 2016 May 5.

Authors

Sumit Sahni¹, Zaklina Kovacevic¹, Danuta S Kalinowski¹, Michael Huang¹, Sharleen Menezes¹, Sukriti Krishan¹, Darius Jr Lane¹, Patric J Jansson¹, Des R Richardson¹

Affiliation

¹ Molecular Pharmacology & Pathology Program, Department of Pathology and the Bosch Institute, Blackburn Building (D06), University of Sydney, Sydney, New South Wales, 2006, Australia.

PMID: 27149429
DOI: 10.4155/fmc-2016-0066

No abstract available

Keywords: N-myc downstream regulated gene 1; autophagy; metastasis.

Publication types

Editorial
Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemical synthesis
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology*
Autophagy / drug effects*
Cell Cycle Proteins / antagonists & inhibitors*
Cell Cycle Proteins / metabolism
Drug Design*
Humans
Intracellular Signaling Peptides and Proteins / antagonists & inhibitors*
Intracellular Signaling Peptides and Proteins / metabolism
Lysosomes / drug effects*
Lysosomes / metabolism
Neoplasms / drug therapy*
Neoplasms / metabolism
Neoplasms / pathology
Thiosemicarbazones / chemical synthesis
Thiosemicarbazones / chemistry
Thiosemicarbazones / pharmacology*
Tumor Microenvironment / drug effects

Substances

Antineoplastic Agents
Cell Cycle Proteins
Intracellular Signaling Peptides and Proteins
N-myc downstream-regulated gene 1 protein
Thiosemicarbazones