Vascular endothelial growth factors (VEGFs) have been shown to participate in atherosclerosis, arteriogenesis, cerebral edema, neuroprotection, neurogenesis, angiogenesis, postischemic brain and vessel repair. Most of these actions involve VEGF-A and the VEGFR-2 receptor. VEGF signaling pathways represent an important potential for treatment of neurological diseases affecting the brain.
V nastoiashchee vremia dokazana rol' semeĭstva VEGF v sleduiushchikh protsessakh, protekaiushchikh v nervnoĭ sisteme: aterogenez, otek golovnogo mozga, neĭroprotektsiia, neĭrogenez, angiogenez, postishemicheskoe vosstanovlenie tkani golovnogo mozga i sosudov. Bol'shinstvo étikh protsessov osushchestvliaetsia za schet aktivnosti VEGF-A i VEGFR-2. Signal'nye puti VEGF predostavliaiut riad vazhnykh potentsial'nykh misheneĭ v terapii nevrologicheskikh zabolevaniĭ, porazhaiushchikh golovnoĭ mozg.
Keywords: (VEGF); VEGF; brain; ischemic stroke; neurogenesis; neuroprotection; vascular endothelial growth factors.