1 School of Chemistry and Chemical Engineering, Shandong University, Jinan, 250100, P. R. China and Key Laboratory for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, Shanghai 200237, P. R. China. zhaocchang@ecust.edu.cn.
2 Department of Neurosurgery, Provincial hospital affiliated to Shandong University, Jinan, 250021, China. 13805311573@126.com.
3 Key Laboratory for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, Shanghai 200237, P. R. China. zhaocchang@ecust.edu.cn.
4 School of Chemistry and Chemical Engineering, Shandong University, Jinan, 250100, P. R. China.
A fluorescent probe for fulfilling a lysosome targeting function in hypoxic tumor cells is reported, wherein azoreductase triggers a dramatic fluorescence enhancement and specific imaging of lysosomes in hypoxic cancer cells.